Because of theophylline’s similarity in structure to caffeine, it produces a well-known caffeine-like side effect profile such as insomnia, nausea, and headache. If side effects persist, or if they make you uncomfortable, notify your doctor. Loss of appetite 7. Theophylline should not be used in pets that are sensitive or allergic to it, or related substances such as theobromine, aminophylline, or caffeine. The medication is also contraindicated in pets suffering from gastric ulcers, epilepsy, liver … Do not use in pets that are allergic to it. Specific therapy differs in acute crises versus chronic management (Table 2). Bronchodilatorsto reduce bronchoconstriction and relieve airflow limitation. Flash Glucose Monitoring in Cats and Dogs. This retrospective case series evaluated theophylline-based therapy in tracheal collapse (TC) canine patients. This retrospective case series evaluated theophylline-based therapy in tracheal collapse (TC) canine patients. ©Copyright VCA Hospitals all rights reserved. Wikipedia article for general information about theophylline However, the patient can still experience side effects with this drug. Aminophyllin is used to relieve cough, wheezing, shortness of breath and troubled breathing. Side effects of theophylline at peak serum greater than 20 mcg/mL include: Heart attack (acute myocardial infarction) Seizures (resistant to anticonvulsants) Urinary retention; This is not a complete list of side effects and other serious side effects may occur. The effects of theophylline on psychomotor functioning and school performance have been examined and have generally shown no significant negative on … Although not all of these side effects may occur, if they do occur they may need medical attention. T… In addition, theophylline can be applied in patients where there are concerns regarding the side-effects of corticosteroids. Euthanasia of Companion Animals. Forty-seven dogs with TC that received theophylline-based therapy during 2013-2017 were investigated. Other side effects include sleeplessness, increased drinking, eating, and urinating. Aminophylline may interact with other medications. It should be used only if the benefits outweigh the risk in pregnant or nursing pets. In dogs, enrofloxacin leads to higher theophylline concentrations by about 30-50%. Theophylline Side Effects. Theophylline Compounded capsule is a blue and white elongated capsule made specifically for your pet. "Dosage Forms Available It can also be given intravenously (into a vein) for treatment for severe asthma attacks or COPD exacerbations. This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver disease or congestive heart failure. The problem is that different brands of theophylline may produce inconsistent blood levels. Theophylline is considered a component of a treatment plan. Theophylline is also used in hospital emergencies. Contact your veterinarian immediately if you observe these side effects in your pet. Electrocution: First Aid. Applies to aminophylline: intravenous solution Along with its needed effects, aminophylline may cause some unwanted effects. Though toxicity in humans starts when blood levels of the drug rise above 20 mcg/mL, dogs are better able to tolerate higher levels. In dogs, however, no side effects are seen until blood levels are enormously out of range so few problems are observed in pets on theophylline. Serious adverse effects can occur at higher doses especially in overdoses. CAUTION: Side effects associated with use of this medication include fever, vomiting, rash, central nervous system excitement, and palpitations. May cause seizures at high doses. Eye Injuries: First Aid . Many drugs are commonly prescribed for off label use in veterinary medicine. If you have side effects early on, they often disappear after the first week of treatment. Do not use in pets that are allergic to it or other opioids, in pets with inflammatory bowel disease, or in pets that have ingested a toxic substance. In humans and dogs, fluoroquinolones inhibit the CYP1A2 metabolism of theophylline. feeling restless or irritable. Older dogs tend to take longer to clear the drug which should also be taken into account. Side-effects of theophylline are often dose dependent and include anorexia, nausea, emesis and headache. Not much is yet known about the adverse effects of this medicine, but the following effects are possible: 1. Theophylline should not be administered to pregnant or nursing dogs (as it can enter the bodies of young pets) or to pets that are to be bred. Anxiety and restlessness are common side effects of treatment in dogs. Theophylline is considered a component of a treatment plan. Side Effects of Aminophylline for Dogs. The medicine is usually given to dogs at a dosage of 4.5 – 6.8 mg/lb every 12 hours (twice daily), or 9 mg/lb once daily using 24-hour extended-release pills. Chronic bronchitis and other airway diseases in dogs Feline asthma and bronchitis Increases heart rate in cases of sick sinus syndrome and heart block Decreases the risk for collapse in cases of vasovagal or tussive syncope (fainting) It also has the ability to increase the release of stomach acid and inhibit contractions of the uterus. 11 year old Maltese with collapsed trachea. On bloodwork, elevated liver enzymes may be … Robitussin Dr. Scott and 87 other Dog Veterinary Specialists are ready to help youDisclaimer: Information in questions, answers, and other posts on this site ("Posts") comes from individual users, not JustAnswer; JustAnswer is not responsible for Posts. Theophylline is intended for use in cats and dogs only. Extended-release tablets are commonly used and tend to peak around 4 – 6 hours after administration in dogs, but the amount of active ingredient that will actually be received from human extended-release pills can vary. The following information is provided as a general guideline only. The suggested dosage of theophylline for dogs is 4.5 to 6.8mg per pound by mouth every 12 hours and for cats 2mg/lbs in every 8-12 hours. Call your doctor for information and medical advice about side effects. Because the drug is not very soluble in fat, it may be necessary to dose by lean body weight in very overweight dogs. By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them. Give as directed by your veterinarian. Theophylline is safe for use on cats and dogs when it is administered under the guidance of a veterinarian. Precautions. Codeine is given by mouth or injection and is used off label to treat mild to moderate pain, cough, and occasionally diarrhea. Like all medicines, theophylline can cause side effects for some people. A change in dose usually minimizes or eliminates side effects. Electrolytes, fluid and heart function will be closely monitored following an overdose. Possible side effects of theophylline. Hence, the key difference between theophylline and aminophylline is that theophylline is more potent and longer-acting than aminophylline. Contributors: Rania Gollakner, BS, DVM, MPH. Theophylline is intended for use in cats and dogs only. Other less serious side effects may also occur. Aminophylline is a combination of theophylline and ethylenediamine. The chart and calculator below should help you find the typical starting dose for your dog. Drowsiness 3. The most common side effects include central nervous system stimulation (excitement) and stomach or intestinal irritation such as nausea, vomiting, and diarrhea. In some cases, blood levels of the medication may be monitored to be sure the dose is correct. Theophylline has been shown to cause stomach irritation and nervous system stimulation. However dogs with the following conditions may not be suitable for treatment: Theophylline interacts with other medicines including some antibiotics, thyroid medication, furosemide, phenobarbital, and many more. Side effects usually subside with dosage adjustments and/or continued therapy. If you miss a dose, give it when you remember, but if it is close to the time for the next dose, skip the dose you missed and give it at the next scheduled time, and return to the regular dosing schedule. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking. It’s best to give the medicine with food to help avoid vomiting. Do not use in pregnant or lactating animals. Side effects of theophylline at peak serum concentration less than 20 mcg/mL include: Central nervous system excitement, headache , insomnia , irritability, restlessness, seizure Diarrhea , nausea , vomiting Glucocorticoidsto reduce airway inflammation 2. Theophylline should be used cautiously with the following medications, as these medications can increase or decrease the effects of theophylline: barbiturates, carbamazepine, activated charcoal, hydantoins, isoniazid, ketoconazole, loop diuretics, rifampin, sympathomimetics, allopurinol, beta-blockers, calcium channel blockers, cimetidine, corticosteroids, fluoroquinolones, macrolides, mexiletine, thiabendazole, and thyroid hormones. Your pet should be monitored for signs of toxicity. It also has slight diuretic properties, meaning it makes a dog pass more water. This medication should take effect within 1 to 2 days, and you should see improvements in your pet’s clinical signs. Drug information provided by: IBM Micromedex. Theophylline is appropriate for use on cats and dogs when it is administered under the guidance of a veterinarian. Adverse reactions associated with theophylline are generally mild when peak serum theophylline concentrations are < 20 mcg/ mL and mainly consist of transient caffeine-like adverse effects such as nausea, vomiting, headache, and insomnia.When peak serum theophylline concentrations exceed 20 mcg/mL, however, theophylline produces a wide range of adverse … One possible treatment option if seizures occur is to administer Valium (diazepam) intravenously, while keeping the airway open. Anxiety and restlessness are common side effects of treatment in dogs. Chest pain or discomfort 2. dizziness 3. fainting 4. fast, slow, or irregular heartbeat 5. increase in urine volume 6. lightheadedness 7. persistent vomiting 8… Possible Side Effects May cause loss of appetite, nausea, vomiting, diarrhea, or nervousness at the beginning of treatment. Find patient medical information for theophylline oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Rarely, uncoordinated walking, seizures, depression, lethargy, allergic reactions, urinary crystals, nervousness have been reported. Pets with liver disease or heart failure should receive lower doses of the medication. Chronic bronchitis and other airway diseases in dogs Feline asthma and bronchitis Increases heart rate in cases of sick sinus syndrome and heart block Decreases the risk for collapse in cases of vasovagal or tussive syncope (fainting) "Dosage Forms Available In dogs, however, no side effects are seen until blood levels are enormously out of range so few problems are observed in pets on theophylline. Actually there are several substitutes: 1) Aminophylline, 2) Terbutaline. I understand you want to find out if there is a substitute for Theophylline to treat for collapsing trachea. Theophylline is used off label to treat cough caused by bronchoconstriction. If body temperature begins to rise too high, phenothiazines may be given, while in the event of a rapid heart rate, propranolol can be used. Along with its needed effects, a medicine may cause some unwanted effects. Theophylline works by relaxing the smooth muscles of the airways while relieving inflam… Do not crush or break the tablets or allow your pet to chew them. Find everything you need to know about Theophylline (Theo-24), including what it is used for, warnings, reviews, side effects, and interactions. Learn who it’s for, how it works, its side effects, warnings, and more. Learn more. The most common side effects are central nervous system stimulation and gastrointestinal upset; particularly nausea and vomiting. Common side effects include sleepiness and constipation. Most commonly, the side effects of Theophylline include central nervous system excitement, vomiting, fever, rash, and heart palpitations. If a negative reaction occurs, please call your veterinary office. It is important that these pills are not chewed or crushed. Check with your doctor immediately if any of the following side effects occur: Incidence not known. Check with your doctor or nurse immediatelyif any of the following side effects occur while taking aminophylline: Incidence not known 1. Plumb’s Veterinary Drugs, Do not use without approval from your vet, Do not give with any other medicines or supplements unless your vet gives you permission, Tell the vet about any illnesses or medical conditions affecting your dog, Use a reduced dosage in dogs with liver failure, COPD (particularly pulmonary hypertension caused by COPD). However, the patient can still experience side effects with this drug. The most common side effects are diarrhea or loose stools, nausea, abdominal pain, and vomiting which may occur in fewer than one in twenty persons who receive azithromycin. Urinate retention In rare cases, it may lead to constipation and vision problems. Metoclopramide. This has lead to theophylline toxicity in humans. It is also sometimes used as adjunctive therapy for pulmonary edema and bronchoconstriction at a dosage of 1.8 – 4.5 mg/lb three times daily. Precautions: Caution should be used when giving aminophylline to dogs with seizure disorders. Possible side effects include anxiety, nervousness and gastrointestinal problems. Theophylline is sometimes given to dogs to treat the following conditions: Not much is yet known about the adverse effects of this medicine, but the following effects are possible: Symptoms of nervous system excitement (such as anxiety and insomnia) and stomach upset tend to pass with repeated use and adjustment of the dosage. Side effects may subside with continued therapy or may require dosage adjustments. Commonly prescribed for off label use in veterinary medicine or without food receiving interact. Treat compulsive behaviors and occasionally used to treat cough drug may help theophylline... 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